Thiazoles: A Retrospective Study on Synthesis, Structure-activity Relationship and Therapeutic Significance

Abstract: Thiazole or 1,3-thiazole is a distinct heterocyclic compound which incorporates sulphur and nitrogen atoms. It vital framework present in numerous pharmacologically active compounds, be it of natural origin synthetic nature. Many thiazoles having antitumor antiviral activities, originate from microbes marine organisms. A variety drugs, thiazole group, like antimicrobial sulfathiazole, antibiotic penicillin, antidepressant pramipexole, antineoplastic agent bleomycin, antiretroviral drug ritonavir, histamine H2 receptor antagonist nizatidine, anti-inflammatory meloxicam, antifungal stilbene derivatives have been the markets for quite some time. Hofmann Hantzsch laid groundwork further development field chemistry. The interaction ?-haloketones ?-halogenaldehyde thioamide to obtain beautifully described by Hantzsch. Various studies reported methods synthesis thiazoles; thioforamide, thiourea, ?-thiocyanotoketones, vinyl bromide extensively employed synthesize thiazoles. immense potential this study tries enlighten crucial role betterment society. review provides different directions novel also reveals diverse targets augmentation designing Keywords: Thiazoles, Synthesis, QSAR, Molecular Docking, Biological Activity